Daflon 500mg is used for the Treatment of the symptoms and signs of organic and idiopathic chronic venous insufficiency of the lower limbs eg, heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
Treatment of the symptoms of acute hemorrhoidal attacks and chronic hemorrhoidal disease.
Usual Dose: Chronic Venous Insufficiency: 2 tabs daily with meals.
Chronic Hemorrhoidal Disease: 2 tabs daily with meals.
Acute Hemorrhoidal Attack: 6 tabs daily (in 2 divided doses) for 4 days, then 4 tabs daily (in 2 divided doses) for 3 days, 2 tabs thereafter.
Daflon 500 mg seems to offer a comprehensive pharmacological answer to all the needs of hemorrhoid treatment. Firstly, the flavonoids, including Daflon 500 mg, have been demonstrated to restain lysosome enzymes and interfere with enzymes involved in the flow of arachidonic acid, which causes inflammation.
Daflon 500 mg has also demonstrated an antioxidant activity, which allows it to oppose free radicals, as well as a decreasing effect on the synthesis of PGE-2 and TXA-2 by the macrophage.
All these effects result in a reduction of the pericapillar permeability, and an increase in the capillary resistance to blood extravasation in the interstitium.
The hemodynamic effect manifests itself through an increase in venous tone demonstrated both experimentally and clinically.
Regarding clinical benefits, two recent studies have demonstrated the outstanding efficacy of Daflon 500 mg, both in acute and recurrent attacks.
All symptoms are significantly improved from the second day of treatment.
A double-blind, placebo-controlled study was performed in 100 patients suffering from hemorrhoidal disease confirmed by proctoscopy, presenting an acute hemorrhoidal attack of up to 3 days, which had not been treated. The treatment lasted 7 days at the dosage of 6 tablets for 4 days and 4 tablets for 3 days.
A clinical examination was performed at D0 and D7, with an assessment of the symptoms and their improvement using a 4-point scale.
The results of this study demonstrated an overall improvement of the symptoms significantly higher in patients treated with Daflon 500 mg in comparison with the controls (P<0.001), which was already evident on the second day of treatment, but more marked at the end. The scores used to evaluate bleeding, pain, and itching resulted in a reduction in both groups on D7, but to a notably greater degree in patients treated with Daflon 500 mg (P<0.001); analogous results were observed regarding tenesmus, with a less relevant resolution percentage and the objective clinical signs (proctitis). Also, the duration and intensity of the present crisis, compared with previously, were much more reduced in patients treated with flavonoids compared with the placebo group (P<0.001)
Learn more about Daflon 500mg here : phlebolymphology.org
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